| 저자(한글) |
장선일,김형진,황기명,권태오,제갈승주,김윤철,배현옥,최병민,심재석,곽준수,정헌택,윤용갑,원광대학교 의과대학 미생물 및 면역학교실,원광대학교 의과대학 미생물 및 면역학교실,원광대학교 의과대학 미생물 및 면역학교실,원광대학교 의약자원연구센터,원광보건대학 임상병리학과,원광대학교 의약자원연구센터,원광대학교 의약자원연구센터,원광대학교 의약자원연구센터,임실생약조합법인 |
| 초록 |
The inhibitory effects of Injinseulki including extracts of melanian snail plus phytomedicinal plants on $CCl_4$-induced fibrosis, $IFN-{ gamma}$ plus LPS-induced production of NO, PMA-stimulated production $O_2$, and tacrine-induced hepatic injury were investigated in rats, RAW 264.7 or HepG2 cells. The ethanol extracts of melanian snail significantly inhibited tarcrine-induced inury of HepG2 cells. Injinseulki inhibited the production of NO and $O_2$ in a dose-dependent manner in activated RAW 264.7 macrophages. Injinseulki significantly inhibited chemical-induced fibrosis in Rats. These results show that Injinseulki including extracts of melanian snail plus phytomedicinal plants may explain some known biological activities of Injinseulki including their anti-inflammatory and anti-fibrotic effect, and is of considerable benefit in the treatment for live diseases. |
