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논문 기본정보
Resveratrol regulates na #x00EF;ve CD 8+ T-cell proliferation by upregulating IFN- #x03B3;-induced tryptophanyl-tRNA synthetase expression
논문 개요
| 기관명 | NDSL |
|---|---|
| 저널명 | BMB reports |
| ISSN | 1976-6696,1976-670x |
| ISBN |
논문저자 및 소속기관 정보
| 저자(한글) | Noh, Kyung Tae,Cho, Joon,Chun, Sung Hak,Jang, Jong-Hwa,Cha, Gil Sun,Jung, In Duk,Jang, Dong Deuk,Park, Yeong-Min |
|---|---|
| 저자(영문) | |
| 소속기관 | |
| 소속기관(영문) | |
| 출판인 | |
| 간행물 번호 | |
| 발행연도 | 2015-01-01 |
| 초록 | We found that resveratrol enhances interferon (IFN)- gamma;-induced tryptophanyl-tRNA-synthetase (TTS) expression in bone marrow-derived dendritic cells (BMDCs). Resveratrol-induced TTS expression is associated with glycogen synthase kinase-3 beta; (GSK-3 beta;) activity. In addition, we found that resveratrol regulates naive CD8 + T-cell polarization by modulating GSK-3 beta; activity in IFN- gamma;-stimulated BMDCs, and that resveratol induces upregulation of TTS in CD8 + T-cells in the in vivo tumor environment. Taken together, resveratrol upregulates IFN- gamma;-induced TTS expression in a GSK-3 beta;-dependent manner, and this TTS modulation is crucial for DC-mediated T-cell modulation. [BMB Reports 2015; 48(5): 283-288] |
| 원문URL | http://click.ndsl.kr/servlet/OpenAPIDetailView?keyValue=03553784&target=NART&cn=JAKO201523050222808 |
| 첨부파일 |
추가정보
| 과학기술표준분류 | |
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| ICT 기술분류 | |
| DDC 분류 | |
| 주제어 (키워드) | Bone marrow-derived dendritic cells,CD8+ T cell,Glycogen synthase kinase 3,Resveratrol,Tryptophanyl-tRNA synthetase |