| 초록 |
OBJECTIVE To investigate the epidemiology of bacterial infections in patients with severe liver disease in intensive care unit (ICU) and analyze the antimicrobial susceptibility of major pathogens to provide reference for clinical therapy. METHODS A retrospective survey was conducted in 206 patients with severe liver disease in ICU of our hospital from Oct 2005 to Dec 2006. Identification and susceptibility of pathogens were assayed by MicroScan Auto-4 System. RESULTS Infection was identified in 70. 87% of the 206 patients with severe liver disease. Most infections were caused by single pathogen. The infection was frequently identified in respiratory tract, blood stream or intra-abdominal cavity. The top 5 pathogens were Escherichia coil (12. 8%), Klebsiegla pneurnoniae (9.9%), Staphylococcus haemol yticus (8.5%), P seudornonas aeruginosa (7.8%) and Stenotroph- omonas maltophilia (6.4%). Gram-negative bacilli were usually resistant to multiple antimicrobial agents, but less resistant to piperacillin-tazobactam or imipenem. Most of S. haemolyticus isolates were meticillin-resistant (MRSH) (25 %), which were susceptible to penicillin, ampicillin and vancomycin. CONCLUSIONS Pathogens of patients with severe liver disease in ICU are mostly multi-drug resistant. The microbiological surveillance is important for guiding clinical therapy. |
