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논문 기본정보
A Novel Piezoelectric Quartz Crystal Microbalance DNA Sensor Based on Nanoparticle
논문 개요
| 기관명 | NDSL |
|---|---|
| 저널명 | 中華醫院感染學雜志 = Chinese journal of nosocomiology |
| ISSN | 1005-4529, |
| ISBN |
논문저자 및 소속기관 정보
| 저자(한글) | XIA, Han,HUANG, Junfu,YAO, Chunyan,WANG, Feng,CHEN, Ming,HUANG, Qing,CAI, Guoru,FU, Weiling |
|---|---|
| 저자(영문) | |
| 소속기관 | |
| 소속기관(영문) | |
| 출판인 | |
| 간행물 번호 | |
| 발행연도 | 2008-01-01 |
| 초록 | OBJECTIVE To construct a novel piezoelectric quartz crystal microbalance (QCM) DNA sensor based on gold nanoparticle. METHODS The nanoparticles were immobilized on the gold surface of DNA sensor with selfassembly method. The pH value and concentrations of probes were optimized respectively. In addition, we detected the PCR products of Pseudomonas aeruginosa with both nanoparticle-based and common piezoelectric QCM DNA sensor array to assess the difference of frequency shift between the 2 sensors. RESULTS The optimum pH value for gold nanoparticle self-assembled was 6.0. The optimum immobilization yield was obtained at 3.0 μmol/L. The sensor could be reused for five times. CONCLUSIONS The nanoparticle-based QCM system we designed has the advantages of being rapid, label-free, and highly response performance and thus can be a useful supplement to clinical assay methods. |
| 원문URL | http://click.ndsl.kr/servlet/OpenAPIDetailView?keyValue=03553784&target=NART&cn=NART51530987 |
| 첨부파일 |
추가정보
| 과학기술표준분류 | |
|---|---|
| ICT 기술분류 | |
| DDC 분류 | |
| 주제어 (키워드) | QCM,Gold nanoparticle,Probe,Biosensor |