- HOME
- 홈페이지 이용안내
논문 기본정보
Osteopontin Potentiates Pulmonary Inflammation and Fibrosis by Modulating IL-17/IFN- gamma;-secreting T-cell Ratios in Bleomycin-treated Mice
논문 개요
| 기관명 | NDSL |
|---|---|
| 저널명 | Immune network : official journal of the Korean association of immunobiologists |
| ISSN | 1598-2629,2092-6685 |
| ISBN |
논문저자 및 소속기관 정보
| 저자(한글) | Oh, Keunhee,Seo, Myung Won,Kim, Young Whan,Lee, Dong-Sup |
|---|---|
| 저자(영문) | |
| 소속기관 | |
| 소속기관(영문) | |
| 출판인 | |
| 간행물 번호 | |
| 발행연도 | 2015-01-01 |
| 초록 | Lung fibrosis is a life-threatening disease caused by overt or insidious inflammatory responses. However, the mechanism of tissue injury-induced inflammation and subsequent fibrogenesis remains unclear. Recently, we and other groups reported that Th17 responses play a role in amplification of the inflammatory phase in a murine model induced by bleomycin (BLM). Osteopontin (OPN) is a cytokine and extracellular-matrix-associated signaling molecule. However, whether tissue injury causes inflammation and consequent fibrosis through OPN should be determined. In this study, we observed that BLM-induced lung inflammation and subsequent fibrosis was ameliorated in OPNdeficient mice. OPN was expressed ubiquitously in the lung parenchymal and bone-marrow-derived components and OPN from both components contributed to pathogenesis following BLM intratracheal instillation. Th17 differentiation of $CD4^+$ ${ alpha}{ beta}$ T cells and IL-17-producing ${ gamma}{ delta}$ T cells was significantly reduced in OPN-deficient mice compared to WT mice. In addition, Th1 differentiation of $CD4^+$ ${ alpha}{ beta}$ T cells and the percentage of IFN- $ gamma$ -producing ${ gamma}{ delta}$ T cells increased. T helper cell differentiation in vitro revealed that OPN was preferentially upregulated in $CD4^+$ T cells under Th17 differentiation conditions. OPN expressed in both parenchymal and bone marrow cell components and contributed to BLM-induced lung inflammation and fibrosis by affecting the ratio of pathogenic IL-17/protective IFN- $ gamma$ T cells. |
| 원문URL | http://click.ndsl.kr/servlet/OpenAPIDetailView?keyValue=03553784&target=NART&cn=JAKO201521059282582 |
| 첨부파일 |
추가정보
| 과학기술표준분류 | |
|---|---|
| ICT 기술분류 | |
| DDC 분류 | |
| 주제어 (키워드) | Osteopontin,Pulmonary fibrosis, lt,TEX gt,${ alpha}{ beta}$ lt,/TEX gt,T cells,IL-17,Th17 differentiation |