| 저자(한글) |
Lee, Keu Sung,Chung, Joo Yang,Jung, Yun Jung,Chung, Wou Young,Park, Joo Hun,Sheen, Seung Soo,Lee, Kyi Beom,Park, Kwang Joo |
| 초록 |
Background: Apoptosis plays a role in the development of pleural effusion. Caspase-cleaved cytokeratin 18, a marker for epithelial cell apoptosis, was evaluated in pleural effusion. Methods: A total of 79 patients with pleural effusion were enrolled. The underlying causes were lung cancer (n=24), parapneumonic effusion (n=15), tuberculous effusion (n=28), and transudates (n=12). The levels of M30, an epitope of caspase-cleaved cytokeratin 18, were measured in blood and pleural fluids using enzyme-linked immunosorbent assay along with routine cellular and biochemical parameters. The expression of M30 was evaluated in the pleural tissues using immunohistochemistry for M30. Results: The M30 levels in pleural fluid were significantly higher in patients with tuberculosis ( $2,632.1{ pm}1,467.3U/mL$ ) than in patients with lung cancer ( $956.5{ pm}618.5U/mL$ ), parapneumonic effusion ( $689.9{ pm}413.6U/mL$ ), and transudates ( $273.6{ pm}144.5U/mL$ ; all p |
