| 저자(한글) |
Campbell, G.M.,Tiwari, S.,Hofbauer, C.,Picke, A.K.,Rauner, M.,Huber, G.,Pena, J.A.,Damm, T.,Barkmann, R.,Morlock, M.M.,Hofbauer, L.C.,Gluer, C.C. |
| 초록 |
Type 2 diabetes mellitus increases skeletal fragility; however, the contributing mechanisms and the efficacy of bone-forming agents are unclear. We studied diabetes and parathyroid hormone (PTH) treatment effects on cortical porosity (Ct.Po), non-enzymatic glycation (NEG) and bone mechanics in Zucker diabetic fatty (ZDF) rats. Eleven-week old ZDF diabetic (DB) and non-diabetic (ND) rats were given 75 mu;g/kg PTH (1-84) or vehicle 5days per week over 12weeks. The right femora and L4 vertebrae were excised, micro-CT scanned, and tested in 3-point bending and uniaxial compression, respectively. NEG of the samples was determined using fluorescence. Diabetes increased Ct.Po (vertebra (vert): +40.6%, femur (fem): +15.5% vs. ND group, p |
