| 저자(한글) |
Brimmo, Olubusola A.,Pfeiffer, Ferris,Bozynski, Chantelle C.,Kuroki, Keiichi,Cook, Cristi,Stoker, Aaron,Sherman, Seth L.,Monibi, Farrah,Cook, James L. |
| 초록 |
Translational models of posttraumatic osteoarthritis (PTOA) that accurately represent clinical pathology need to be developed. This study assessed a novel canine model for PTOA using impact injury. Impacts were delivered to the medial femoral condyle of dogs using a custom-designed impactor at 20, 40, or 60 MPa. Functional assessments and magnetic resonance imaging (MRI) were performed at 2 and 12 weeks, and arthroscopic and histologic assessments were performed at 12 weeks after injury. At 2 and 12 weeks, dogs had observable lameness, knee pain, effusion, loss in range of motion (ROM) and dysfunction in both hindlimbs with severity correlated strongly (r thinsp; gt; thinsp;0.77) to impact level. At 12 weeks, function, pain, effusion, and ROM were significantly (p thinsp; |
