| 저자(한글) |
Zhang, Y.,Kapur, P.,Yuan, Q.,Xi, Y.,Carvo, I.,Signoretti, S.,Dimitrov, I.,Cadeddu, J.A.,Margulis, V.,Muradyan, N.,Brugarolas, J.,Madhuranthakam, A.J.,Pedrosa, I. |
| 초록 |
Background: The objective of this study was to investigate potential correlations between perfusion using arterial spin-labeled (ASL) magnetic resonance imaging (MRI) and dynamic contrast-enhanced (DCE) MRI-derived quantitative measures of vascularity in renal masses gt; 2 cm and to correlate these with microvessel density (MVD) in clear cell renal cell carcinoma (ccRCC). Patients and Methods: Informed written consent was obtained from all patients before imaging in this Health Insurance Portability and Accountability Act-compliant, institutional review board-approved, prospective study. Thirty-six consecutive patients scheduled for surgery of a known renal mass gt; 2 cm underwent 3T ASL and DCE MRI. ASL perfusion measures (P ASL ) of mean, peak, and low perfusion areas within the mass were correlated to DCE-derived volume transfer constant (K trans ), rate constant (Kep), and fractional volume of the extravascular extracellular space (Ve) in the same locations using a region of interest analysis. MRI data were correlated to MVD measures in the same tumor regions in ccRCC. Spearman correlation was used to evaluate the correlation between P ASL and DCE-derived measurements, and MVD. P ASL correlated with K trans ( rho; = 0.48 and P = .0091 for the entire tumor and rho; = 0.43 and P = .03 for the high flow area, respectively) and Kep ( rho; = 0.46 and P = .01 for the entire tumor and rho; = 0.52 and P = .008 for the high flow area, respectively). P ASL ( rho; = 0.66; P = .0002), K trans ( rho; = 0.61; P = .001), and Kep ( rho; = 0.64; P = .0006) also correlated with MVD in high and low perfusion areas in ccRCC. Conclusion: P ASL correlated with the DCE-derived measures of vascular permeability and flow, K trans and Kep, in renal masses gt; 2 cm in size. Both measures correlated to MVD in clear cell histology. |
