| 저자(한글) |
박두상,윤미애,서명철,유하나,김주령,정태숙,박호용,한국생명공학연구원 곤충자원연구실,한국생명공학연구원 곤충자원연구실,한국생명공학연구원 곤충자원연구실,한국생명공학연구원 지질대사연구실,한국생명공학연구원 지질대사연구실,한국생명공학연구원 지질대사연구실,한국생명공학연구원 곤충자원연구실 |
| 초록 |
Lipoprotein-associated phospholipase $A_2 ;(Lp-PLA_2)$ is a potential biomarker of coronary heart disease and plays an important proinflammatory role in the progression of atherosclerosis. Also acyl-CoA: cholesterol acyltransferase (ACAT) and oxidized low-density lipoprotein (LDL) playa key role in atherosclerosis, respectively. And so, the inhibitory activities of the methanol extracts of 42 insect resources were examined on $Lp-PLA_2$, ACAT, and LDL oxidation for screening of anti-atherogenic substances. Among them, the methanol extracts of Eurydema rugosa significantly inhibited all of upper three activities. Several kinds of tested insects having high inhibitory effect with the methanol extracts were extracted with n-hexane, ethyl acetate, and acetone, and their inhibitory activities were tested. |
