| 저자(한글) |
Huang, Le,You, Yong-ke,Zhu, Tracy Y,Zheng, Li-zhen,Huang, Xiao-ru,Chen, Hai-yong,Yao, Dong,Lan, Hui-yao,Qin, Ling |
| 초록 |
This study aimed to evaluate the validation of the leptin receptor-deficient mice model for secondary osteoporosis associated with type 2 diabetes mellitus (T2DM) at bone micro-architectural level. Thirty three 36-week old male mice were divided into four groups: normal control (db/m) (n thinsp;= thinsp;7), leptin receptor-deficient T2DM (db/db) (n thinsp;= thinsp;8), human C-reactive protein (CRP) transgenic normal control (crp/db/m) (n thinsp;= thinsp;7), and human CRP transgenic T2DM (crp/db/db) (n thinsp;= thinsp;11). Lumber vertebrae (L5) and bilateral lower limbs were scanned by micro-CT to analyze trabecular and cortical bone quality. Right femora were used for three-point bending to analyze the mechanical properties. Trabecular bone quality at L5 was better in db/db or crp/db/db group in terms of bone mineral density (BMD), bone volume fraction, connectivity density, trabecular number and separation (all p thinsp; thinsp;0.05). Maximum loading and energy yield in mechanical test were similar among groups while the elastic modulus in db/db and crp/db/db significantly lower than db/m. The leptin-receptor mice is not a proper model for secondary osteoporosis associated with T2DM. |
