분비나무 줄기 수피 추출물에 의한 HeLa Cell Line의 증식억제 효과와 RAW264.7 세포에서 Lipopolysaccharide에 의해 유도된 Nitric Oxide 생성 저해효과
기관명 | NDSL |
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저널명 | 생약학회지 |
ISSN | 0253-3073, |
ISBN |
저자(한글) | 배기은,정한수,김동섭,최영웅,김영숙,김영균,국민대학교 임산공학과,국민대학교 임산공학과,국민대학교 임산공학과,국민대학교 임산공학과,국민대학교 임산공학과,국민대학교 임산공학과 |
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저자(영문) | |
소속기관 | |
소속기관(영문) | |
출판인 | |
간행물 번호 | |
발행연도 | 2009-01-01 |
초록 | Abies nephrolepis(Pinaceae) extracts were tested for determined immune system regulating activity based on antiinflammatory activity, antioxidant activity and anti-proliferative effect on HeLa cell line. The A. nephrolepis extracts increased dose-dependently anti-proliferation of HeLa cell line. The DM fraction of the extracts having anti-proliferatative effects of HeLa cell line was fractionalized four subfractions($D1{ sim}D4$). Inflammation-induced NO production was inhibited by D2 and D4 in LPS-activated RAW264.7 macrophages. And also, this fractions showed antioxidant activity examined by DPPH radical scavenging effects. These results suggest that the potential use of DM fraction of A. nephrolepis in chemoprevention and regulation overproduction of NO on pathogenic conditions. The mechanism of the inflammatory effects, however, must be evaluated through various parameters in the induction cascade of NO production. |
원문URL | http://click.ndsl.kr/servlet/OpenAPIDetailView?keyValue=03553784&target=NART&cn=JAKO200914852871262 |
첨부파일 |
과학기술표준분류 | |
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ICT 기술분류 | |
DDC 분류 | |
주제어 (키워드) | Abies nephrolepis,Pinaceae,Antioxidant,Antiinflammation,Anticancer |