| 저자(한글) |
Selvakumaran, S.,Muhamad, I.I.,Abd Razak, S.I. |
| 저자(영문) |
|
| 소속기관 |
|
| 소속기관(영문) |
|
| 출판인 |
|
| 간행물 번호 |
|
| 발행연도 |
2016-01-01 |
| 초록 |
Floating hydrogels were prepared from kappa carrageenan containing CaCO 3 and NaHCO 3 as pore forming agents. The effects of CaCO 3 and NaHCO 3 on hydrogel characterizations were investigated and compared. Amoxicillin trihydrate was used as a model drug. Characterizations of the hydrogels were carried out using Fourier transform infrared spectroscopy (FTIR), X-ray diffraction (XRD) and field emission scanning electron microscope (FESEM). As pore forming agents concentration increases, the porosity (%) and floating properties increased. NaHCO 3 incorporated hydrogels showed higher porosity with shorter floating lag time (FLT) than CaCO 3 . Hydrogel which contained CaCO 3 exhibited better gel stability over the control and NaHCO 3 containing gel. Incorporation of CaCO 3 into kappa carrageenan hydrogel showed smoother surface gels compared to those produced with NaHCO 3 . CaCO 3 also showed higher drug entrapment efficiency and sustained drug release profile than NaHCO 3 . The results of these studies showed that, CaCO 3 is an effective pore forming agents in kappa;C hydrogels preparation as compare to NaHCO 3 . Thus, CaCO 3 can be an excellent pore forming agent for an effective floating drug delivery system. |
| 원문URL |
http://click.ndsl.kr/servlet/OpenAPIDetailView?keyValue=03553784&target=NART&cn=NART73232351 |
| 첨부파일 |
|
