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논문 기본정보
약물대사효소 CYP2D6와 N-acetyltransferase 활성의 고령화에 따른 변화에 관한 연구
논문 개요
| 기관명 | NDSL |
|---|---|
| 저널명 | Translational and Clinical Pharmacology |
| ISSN | , |
| ISBN |
논문저자 및 소속기관 정보
| 저자(한글) | 배균섭 |
|---|---|
| 저자(영문) | |
| 소속기관 | |
| 소속기관(영문) | |
| 출판인 | |
| 간행물 번호 | |
| 발행연도 | 2002-01-01 |
| 초록 | Background : The effect of age on the activity of drug metabolizing enzymes has not been studied thoroughly. We examined the effect of age on the metabolic activity of CYP2D6 and N-acetyltransferase.Methods : Metoprolol and isoniazid were used as probe drugs of CYP2D6 and N-acetyltransferase, respectively. We measured metabolic ratios of metoprolol and isoniazid in 80 subjects of 21~85 years old. Metabolic ratio(MR) of metoprolol was defined as the ratio of metoprolol/α-hydroxymetoprolol in the urine collected for 8 hours after the administration. Isoniazid/acetylisoniazid was used for MR of isoniazid. Concentrations of parent drug and metabolite were assayed by HPLC simultaneously. General linear model in SAS 8.1ⓡ was used for the statistical analysis after visual exploration. Metabolic ratios were log-transformed to be normalized for analysis.Results : Demographic characteristics were similar between groups of metabolic activities. MRs of both drugs were not significantly different between groups by age, sex and smoking. Mean MR of metoprolol for adult group(age |
| 원문URL | http://click.ndsl.kr/servlet/OpenAPIDetailView?keyValue=03553784&target=NART&cn=ART001450502 |
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추가정보
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