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논문 기본정보
Preparation of [68Ga]PSMA-11 for PET-CT imaging using a manual synthesis module and organic matrix based 68Ge/68Ga generator
논문 개요
| 기관명 | NDSL |
|---|---|
| 저널명 | Nuclear medicine and biology |
| ISSN | 0969-8051, |
| ISBN |
논문저자 및 소속기관 정보
| 저자(한글) | Nanabala, R.,Anees, M.K.,Sasikumar, A.,Joy, A.,Pillai, M.R.A. |
|---|---|
| 저자(영문) | |
| 소속기관 | |
| 소속기관(영문) | |
| 출판인 | |
| 간행물 번호 | |
| 발행연도 | 2016-01-01 |
| 초록 | Introduction: [ 68 Ga]PSMA-11 is a relatively recently introduced radiopharmaceutical for PET-CT imaging of prostate cancer patients. The availability of 68 Ge/ 68 Ga generator and PSMA-11 ligand from commercial sources is facilitating the production of the radiopharmaceutical in-house. This paper describes our experience on the preparation of ~200 batches of [ 68 Ga]PSMA-11 for conducting PET-CT imaging in patients suspected/suffering from prostate cancer. Methods: The radiosynthesis of [ 68 Ga]PSMA-11 was done in a hospital based nuclear medicine department using 68 Ge/ 68 Ga generator and a manual synthesis module, both supplied by Isotope Technologies Garching (ITG), Germany. The production involved the reaction of 5 mu;g (5.3nmol) of PSMA-11 ligand in 1 ml of 0.25M sodium acetate buffer with 4ml of 68 GaCl 3 in 0.05M HCl for 5min at 105 o C; followed by purification in a C18 cartridge and collection through a 0.22 mu;m pore size filter. Results: The radiochemical yields obtained were consistently high, 93.19%+/-3.76%, and there was hardly any batch failure. The radiochemical purity of the product was gt;99% and the product was stable for over 2h; however it was used in patients immediately after preparation. About 200 batches of [ 68 Ga]PSMA-11 were prepared during the period and more than 300 patients received the tracer during the 14months of study. No adverse reaction was observed in any of the patients and the image qualities were consistent with literature reports. Conclusion: [ 68 Ga]PSMA-11 with high radiochemical and radionuclidic purity is conveniently prepared by using a 68 Ge/ 68 Ga generator and manual synthesis module. The radiochemical yields are very high; and activity sufficient for 3-4 patients can be prepared in a single batch; multiple batches can be done on the same day and when needed after a gap of 1.5-2h. |
| 원문URL | http://click.ndsl.kr/servlet/OpenAPIDetailView?keyValue=03553784&target=NART&cn=NART75968360 |
| 첨부파일 |
추가정보
| 과학기술표준분류 | |
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| ICT 기술분류 | |
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| 주제어 (키워드) | lt,SUP gt,68 lt,/SUP gt,Ge/ lt,SUP gt,68 lt,/SUP gt,Ga generator, lt,SUP gt,68 lt,/SUP gt,Ga-PSMA-11,PET-CT imaging,Prostate cancer,PSMA inhibitor,Radiolabeling |