| 저자(한글) |
Nakaya, Koji,Otsuka, Hideki,Kondo, Kazuya,Otani, Tamaki,Nagata, Motoi |
| 저자(영문) |
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| 소속기관 |
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| 소속기관(영문) |
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| 출판인 |
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| 간행물 번호 |
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| 발행연도 |
2016-01-01 |
| 초록 |
INTRODUCTION: We administered an angiotensin-converting enzyme inhibitor (captopril) to mice implanted with a human lung adenocarcinoma epithelial cell line (A549 cells) and investigated the tumor growth-inhibitory effect of captopril from the viewpoint of glucose metabolism using F-fluorodeoxyglucose (F-FDG)-PET/CT. METHODS: Subcutaneous implantation of A549 cells (1.9×10 cells) was carried out in the lower right flank of mice. Fifteen days after the transplantation of A549 cells, mice (six in each group) were treated with captopril (3.0 mg/mouse) or saline (1000 mu;l/mouse) for 5 days. We performed F-FDG-PET/CT imaging of the mice before and after the treatment and evaluated the degree of F-FDG accumulation in tumors. In both groups (the captopril-administrated and control groups), values for the metabolic tumor volume (MTV), maximum standardized uptake value, total lesion glycolysis, and tumor volume after treatment had a tendency to increase. However, tumor growth was suppressed in the captopril-administrated group compared with the control group. RESULTS: In terms of the growth rate, the MTV and tumor volume were significantly different (P |
| 원문URL |
http://click.ndsl.kr/servlet/OpenAPIDetailView?keyValue=03553784&target=NART&cn=NART74673639 |
| 첨부파일 |
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